CLINDAMYCIN INJ 300mg/ 2ml ( INJECTIONS ) Manufacturer | Supplier | Franchise

Clindamycin Inj 300mg/ 2ml- It is a prescription injection which is used to treat serious bacterial infections of blood, lungs, skin, abdomen, and soft tissues. The medicine works by blocking bacterial protein synthesis. It is administered via IV or IM injection. 

Clindamycin injection is a highly credible, clinically trusted, and widely used parenteral antibiotic. This is primarily valued for its efficacy towards serious gram-positive and anaerobic bacterial infections. It is a lincosamide antibiotic that is considered as a cornerstone treatment in hospitals when penicilin cannot be.

Clindamycin is known for its ability to penetrate deep into tissues including bones, and is highly concentrated within phagocytes.

Medxone Healthcare supplies this injection under the brand name Clinxone 300 . The injection is commonly used as a surgical prophylactic agent in operating rooms to prevent infection, often in cases where cefazolin is not suitable.

Mechanism of Clindamycin Injection 

Clindamycin binds to the 23S RNA of the 50S ribosomal subunit, which interrupts the translation process. It is highly effective against anaerobic bacteria and gram-positive aerobes, including Sreptococcus pneumoniae, Staphylococcus aureus, and Clostridium perfringens. 

Although it is infected as Clindamycin phosphate, it is rapidly hydrolysed in vivo to the active, free clindamycin molecule.

It is resistant to commonly occurring via modification of the 23S ribosomal RNA, which can also lead to cross-resistance with macrolides and streptogramin B. By blocking protein production, it also helps in reduction of production of bacterial toxins.  

Benefits of Clindamycin Injection 

• As a parenteral medication, it acts almost immediately with noticeable improvement within 1 hour.
• It is effective against Staphylococcus, Streptococcus, and various anaerobic bacteria, including some MRSA cases.
• It is used for serious infections, including intra-abdominal infections, pelvic inflammatory disease, septicemia, and bone/joint infections.
• It is commonly used for patients with penicilin allergies.
• It reduces the risk of severe, long-term health problems caused by spreading infections.

Side Effects of Clindamycin Injection 

• Vomiting
• Stomach Pain
• Irritation at injection site
• Pain at injection site
• Metallic taste in mouth 

Precautions of  Clindamycin Injection 

Clindamycin injection should be used carefully in some patients. Always tell your doctor if you have any allergies or existing health problems. Proper precautions can help ensure safe and effective treatment. The key precautions are mentioned below.

• Clindamycin is related to severe, potentially fatal Clostridium difficile-related diarrhea.
• Intravenous (IV) doses must be diluted and infused slowly and never administered as an undiluted bolus.
• Serious, fatal, and life-threatening allergic reactions like anaphylaxis can occur.
• Inform your doctor if you have a history of allergies, asthma, colitis, or liver/kidney disease.    
• For prolonged therapy, check liver and kidney function, especially in infants.
• Some formulations contain benzyl alcohol, which can cause fatal “gasping symdrome” in newborns.

Frequently Asked Questions (FAQs)

Q1- Why is Clindamycin injection given instead of capsules?

A- The injection is used in the treatment of severe, systemic or deep-seated infections that require immediate concentration of medicine in the blood.

Q2- Is Clindamycin injection safe for children?

A- It is safe for children over 1 month of age when used to treat serious bacterial infections.

Q3- Can Clindamycin injection cause liver problems?

A- The injection can cause liver problems in rare cases. Symptoms of liver disease include yellowing of the skin or eyes. 

Q4- Who should not take Clindamycin injection?

A- Individuals with hypersensitivity or allergic reaction to Clindamycin, lincomycin, or any component of the injection. 

Q5- Is Clindamycin injection suitable for throat infection?

A- Clindamycin injection is effective for severe throat infections and is suitable when pateints are allergic to penicillin. 

Q6- Why do we have to wait for 30 minutes after taking Clindamycin?

A- We should wait to prevent throat irritation or esophageal damage.

Q7- Does clindamycin affect blood pressure?

A- It can lower down the blood pressure due to too-rapid intraveneous administration.